We are proud to share an exciting milestone from the Horvath Lab, highlighting the contributions of our PI, Anelia Horvath, PhD, and collaborators in the current issue (March 2026) of The Journal of Precision Medicine: Health and Disease.
The article, “Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart,” provides one of the first direct, large-scale comparisons between human iPSC-derived cardiomyocytes and adult human heart tissue using deep RNA sequencing and advanced computational modeling.
The findings show strong similarity in gene expression-especially for cardiac ion channels and transcription factors-supporting iPSC-CMs as a reliable, scalable human model.
Key highlights:
- Overlap in electrophysiology-related gene expression between iPSC-CMs and adult heart tissue
- Key roles of HDACs, SIRTs, and transcription factors in ion channel regulation
- Epigenetic influence on cardiac excitability and function
- iPSC-CMs as a platform for cardiotoxicity testing and precision medicine